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Together, the adoption of a standardized cuprizone administration protocol improved inter-study reliability and by using the C57BL/6 inbred mouse strain, provided better options for conducting studies on transgenic mice, many of which are bred to a C57BL/6 background

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and day 3 (HE (upper), Mallory (middle) staining, 40): wide gap ( c ), great amount of inflammatory cells, collagen (green fibers, Mallory staining) only in mucosa and submucosa ( d )

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H., Zehrer C., Niethammer D., Sailer E

So that suggests if they've been relaxed, that suggests that they used to be that there used to be norms of that were more inhibitory